Effect of hydroalcoholic extract of Berberis integerrima and resveratrol on ovarian morphology and biochemical parameters in Letrozole-induced polycystic ovary syndrome. - GreenMedInfo Summary
Effect of hydroalcoholic extract ofand resveratrol on ovarian morphology and biochemical parameters in Letrozole-induced polycystic ovary syndrome rat model: An experimental study.
Int J Reprod Biomed. 2020 Aug ;18(8):637-650. Epub 2020 Aug 19. PMID: 32923930
Fatemeh Ashkar
BACKGROUND: Resveratrol and() are known to be natural antioxidants and regulators of human metabolism. However, the effects of resveratrol andon the ovarian morphology in polycystic ovary syndrome (PCOS) are not obvious.
OBJECTIVE: This study aimed to determine the effect of the hydroalcoholic extract ofin combination with resveratrol on some biochemical parameters and ovarian morphology in the letrozole-induced PCOS rat.
MATERIALS AND METHODS: Seventy adult female Sprague-Dawley rats aged 10-12 weeks weighing 20020 gr were randomly divided into seven groups (n = 10/each). Group I): normal; Group II): vehicle; Group III): letrozole-induced PCOS 1 mg/kg letrozole orally, rats receiving 1 cc normal saline orally; Group IV): PCOS + receiving 150 mg/kg metformin orally; Group V): PCOS + receiving 20 mg/kg resveratrol orally; Group VI): PCOS + 3 gr/kg barberry orally; and Group VII): PCOS + receiving 3 gr/kg barberry and 20 mg/kg resveratrol orally. All animals were followed-up for 63 days. The biochemical parameters and histological assessments of ovaries were performed.
RESULTS: Resveratrol alone and/or in combination withtreatment in rats led to a significant decrease in low-density lipoprotein, triglyceride, malondialdehyde, and tumor necrosis factor-alpha concentrations (p = 0.02). The groups IV, V, VI, and VII showed a decrease in insulin resistance and an increase in the superoxide dismutase, total antioxidant capacity, and high-density lipoprotein (p = 0.01). No significant difference was observed between the level of serum glucose in the treatment groups. Number of cystic follicles had a significant decrease in barberry, resveratrol, and their combination groups (p0.001).
CONCLUSION: Resveratrol,, and their combination as natural products with fewer side effects might be effective as an alternative medicine in treatment of PCOS.
