Article Publish Status: FREE
Abstract Title:

Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury.

Abstract Source:

Eur J Clin Nutr. 2021 Jan 29. Epub 2021 Jan 29. PMID: 33514869

Abstract Author(s):

Xuelong Li, Ying Liu, Xiaofei Guo, Yan Ma, Huaqi Zhang, Hui Liang

Article Affiliation:

Xuelong Li


BACKGROUND: The present study aims to investigate the effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury.

METHODS: In a double-blind randomized controlled trial, 158 recruited alcoholic liver injury patients were randomized to three treatments for 60 days: low-dose group (LP, n = 58, 100 ml of Lactobacillus casei strain Shirota (LcS)), high-dose group (HP, n = 54, 200 ml of LcS), and positive control group (PC, n = 46, 100 ml of special drinks without active Lactobacillus casei). Another group of 20 healthy people was served as normal control group (NC).

RESULTS: The serum levels of TG and LDLC in the HP group were significantly decreased by 26.56% and 23.83%, respectively than those in the PC group (P < 0.05). After supplementation of Lactobacillus casei, there was a significant increase in the amount of Lactobacillus and Bifidobacterium when compared with the PC group (P < 0.05).

CONCLUSIONS: Supplementation of Lactobacillus casei can improve lipid metabolism and regulate intestinal flora disorders in patients with alcoholic liver injury.

Study Type : Human Study

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Sayer Ji
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