Abstract Title:

The effect ofon oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis.

Abstract Source:

J Complement Integr Med. 2021 Jan 5 ;18(2):235-259. Epub 2021 Jan 5. PMID: 34187123

Abstract Author(s):

Sanaz Malekian, Nafiseh Ghassab-Abdollahi, Mojgan Mirghafourvand, Azizeh Farshbaf-Khalili

Article Affiliation:

Sanaz Malekian


OBJECTIVES: The present systematic review of literature was conducted to study the effect of() on oxidative stress and inflammatory biomarkers.

CONTENT: Different online databases such as Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), Scopus, Web of Sciences, EMBASE, and Clininaltrial.gov for English articles and national databases of SID, Magiran, Irandoc, and Iranmedex for Persian articles, which were published until March; 2019 were scrutinized. All Randomised Controlled Trials (RCTs) and quasi-experimental studies that aimed to compare the impact ofalong, with placebo or without supplementation, on inflammatory factors and oxidative stress were entered in the present study.

SUMMARY: Finally, 11 RCTs covering 710 women and men, in total, were participated in the present meta-analysis. Significant differences were observed in Tumor Necrosis Factor alpha (TNF-α) (Weighted Mean Difference (WMD) =-2.15 pg/mL, 95% Confidence Interval (CI) =-3.22--1.09, I=32%; 5 trials with 262 participants) superoxide dismutase (WMD=63.79 µ/gHb, 95% CI=6.84-120.75, I=0%; 2 trials, with 88 participants), and total antioxidant capacity (WMD=0.34 mmol/L, 95% CI=0.04 to 0.63, I=94%; 5 trials with 232 participants). Nevertheless, there was no significant difference in high sensitivity C-reactive protein (WMD=-0.98 mg/L, 95% CI=-1.98-0.03, I=78%; 5 trials with 267 participants), Interleukin 6 (IL-6) (WMD=-0.25 pg/mL, 95% CI=-0.65 to 0.16, I=0%; 2 trials with 134 participants), and malondialdehyde (WMD=-0.95 nmol/mL, 95% CI=-1.97-0.08, I=68%; 4 trials with 179 participants).

OUTLOOK: Generally speaking,probably results in the improvement of superoxide dismutase serum levels, TNF-α, and total antioxidant capacity. Thus, further studies are required to fully assess its impacts on all oxidative stress and inflammatory biomarkers.

Study Type : Meta Analysis, Review

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.