Abstract Title:

Effect of paeonol against bacterial growth, biofilm formation and dispersal ofand.

Abstract Source:

Biofouling. 2022 Feb 23:1-13. Epub 2022 Feb 23. PMID: 35196921

Abstract Author(s):

Qiao Zeng, Yuting Fu, Min Yang, Ting Wang, Ying Wang, Shenghua Lv, Weidong Qian

Article Affiliation:

Qiao Zeng


Previous studies have demonstrated the antibacterial activity of paeonol against bacterial pathogens, but its anti-biofilm activities againstandremain largely unexplored. Here, the antibacterial and anti-biofilm activities of paeonol againstandwere examined using the crystal violet staining assay (CVSA), field emission scanning electron microscopy (FESEM), and confocal laser scanning microscopy (CLSM) analysis. Paeonol effectively inhibited the growth ofandwith a minimum inhibitory concentration (MIC) of 500 and 125 μg ml, respectively, and disrupted the integrity of cell membranes. Moreover, sub-MIC paeonol exhibited an inhibitory effect on the attachment ofandto the abiotic surface and biofilm formation. Further, paeonol effectively destroyed cell membranes within biofilms, and dispersed mature biofilms of both strains. The results indicate that paeonol might be a promising antibacterial and anti-biofilm agent for combating infections caused byand.

Study Type : In Vitro Study

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Sayer Ji
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