n/a
Article Publish Status: FREE
Abstract Title:

Effect of Vitamin D Supplementation on Glycemic Control in Prediabetes: A Meta-Analysis.

Abstract Source:

Nutrients. 2021 Dec 14 ;13(12). Epub 2021 Dec 14. PMID: 34960022

Abstract Author(s):

Yujing Zhang, Yuan Xue, Dongdong Zhang, Yaping Liu, Ze Xu, Jiaojiao Gao, Wenjie Li, Xing Li

Article Affiliation:

Yujing Zhang

Abstract:

Clinical research results of vitamin D supplementation in the improvement of prediabetes remain controversial. Accordingly, a literature search was conducted of PubMed, Embase (Ovid), and Web of Science prior to 9 November 2021. Randomized controlled studies reported that the following indicators were included: body mass index (BMI), fasting blood glucose (FBG), 2 h oral glucose tolerance test plasma glucose (2h-PG), hemoglobin A1c (HbA1c), insulin resistance by homeostasis model assessment (HOMA-IR), homeostasis model assessment ofβ-cell function (HOMA-B), and fasting insulin (FINS). Twenty-nine articles (= 3792) were included in the present meta-analysis. Intriguingly, vitamin D supplementation resulted in a vast improvement in FBG (standardized mean difference (SMD) = -0.38; 95%CI: -0.59, -0.16), HbA1c (SMD = -0.14; 95%CI: -0.22, -0.06) and FINS (SMD = 0.18; 95%CI: -0.26, -0.09), but not in other outcomes. However, preferred changes were observed in subgroups, as follows: Asia (SMD= -0.25, 95%CI: -0.45, -0.04), study duration≥1 year (SMD= -0.44, 95%CI: -0.81, -0.06) (SMD= 0.34, 95%CI: 0.01, 0.66), baseline 25(OH)D<50 nmol/L (SMD= -0.23, 95%CI: -0.39, -0.06), and baseline 25(OH)D≥ 50 nmol/L (SMD= -0.50, 95%CI: -0.96, -0.03). In conclusion, oral supplementation of vitamin D has shown better effects in improving FBG, HbA1c, and FINS compared with controls among prediabetics; long-term vitamin D supplementation could have additional effects in participants with vitamin D deficiency for 2h-PG, HOMA-IR, and HOMA-B.

Study Type : Meta Analysis

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.