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Abstract Title:

Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatric ambulatory surgery.

Abstract Source:

Cir Cir. 2010 ;78(5):400-9. PMID: 21219810

Abstract Author(s):

Alfonso Galván-Montaño, Gerardo Reyes-García, María de Lourdes Suárez-Roa, Juan Asbun-Bojalil

Article Affiliation:

Alfonso Galván-Montaño

Abstract:

BACKGROUND: analgesics in pediatric ambulatory surgery must be safe and effective. Acetominophen is safe with moderate efficacy; therefore, we searched for other drugs. In preclinical trials, improved efficacy was reported with the combination of acetaminophen + B vitamins. The aim of this study was to determine the analgesic efficacy of acetaminophen + B vitamins in pediatric ambulatory surgery.

METHODS: we conducted a clinical, comparative, randomized, double-blind study. We included 56 patients who were divided into four groups of 14 patients for each surgery (circumcision, tonsillectomy, inguinal hernioraphy, orchiopexy). Half of the patients received acetaminophen + B vitamins, and the remaining patients received acetaminophen alone. Variables were drugs, visual analogue scale and time of discharge.χ(2), Student t-test and analysis of variance (ANOVA) were used for statistical analysis.

RESULTS: in children who received acetaminophen + B vitamins during the immediate postoperative period, 58% had a pain score<2 and 89% were discharged with a pain score %lt;1. Both schedules were effective and safe but acetaminophen + B vitamins showed a better pain score.

CONCLUSIONS: the adjuvant effect of B vitamins was demonstrated with a better pain score in the immediate postoperative period and at the time of discharge.

Study Type : Human Study

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