The effects ofβ-elemene on the expression of mTOR, HIF-1A, survivin in lung adenocarcinoma A549 cell.
Afr J Tradit Complement Altern Med. 2013 ;10(4):18-23. Epub 2013 May 16. PMID: 24146496
The purpose of this manuscript was to study the regulation effects ofβ-elemene combined with radiotherapy on three different gene expressions in lung adenocarcinoma A549 cell. mTOR gene, HIF-1α gene, Survivin gene were included in the gene group. Cell culture and RT-PCR were applied to finish this research. Hypoxia Control group, Hypoxia β-elemene group, Hypoxia β-elemene combined with irradiation group were set to compare the differences of three different gene expressions. The most active effects were found in the group of Hypoxia irradiation combined with β-elemene. In this group, the mTOR gene, HIF-1α gene, Survivin gene expressions were all down-regulated when compared with the single treatment groups, and there were significantly statistical differences.