Article Publish Status: FREE
Abstract Title:

Effects of internalized gold nanoparticles with respect to cytotoxicity and invasion activity in lung cancer cells.

Abstract Source:

PLoS One. 2014 ;9(6):e99175. Epub 2014 Jun 5. PMID: 24901215

Abstract Author(s):

Zhengxia Liu, Yucheng Wu, Zhirui Guo, Ying Liu, Yujie Shen, Ping Zhou, Xiang Lu

Article Affiliation:

Zhengxia Liu


The effect of gold nanoparticles on lung cancer cells is not yet clear. In this study, we investigated the cytotoxicity and cell invasion activity of lung cancer cells after treatment with gold nanoparticles and showed that small gold nanoparticles can be endocytosed by lung cancer cells and that they facilitate cell invasion. The growth of A549 cells was inhibited after treatment with 5-nm gold nanoparticles, but cell invasion increased. Endocytosed gold nanoparticles (size, 10 nm) notably promoted the invasion activity of 95D cells. All these effects of gold nanoparticles were not seen after treatment with larger particles (20 and 40 nm). The enhanced invasion activity may be associated with the increased expression of matrix metalloproteinase 9 and intercellular adhesion molecule-1. In this study, we obtained evidence for the effect of gold nanoparticles on lung cancer cell invasion activity in vitro. Moreover, matrix metalloproteinase 9 and intercellular adhesion molecule-1, key modulators of cell invasion, were found to be regulated by gold nanoparticles. These data also demonstrate that the responses of the A549 and 95D cells to gold nanoparticles have a remarkable relationship with their unique size-dependent physiochemical properties. Therefore, this study provides a new perspective for cell biology research in nanomedicine.

Study Type : In Vitro Study

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