Effects of nondigestible oligosaccharides on obesity. - GreenMedInfo Summary

Obesity is a major public health concern that has almost reached the level of pandemic and is rapidly progressing. Gut microbiota has emerged as a crucial regulator involved in the etiology of obesity, and the manipulation of it by dietary intervention has been widely used for reducing the risk of obesity. Nondigestible oligosaccharides (NDOs) are attracting increasing interests as prebiotics, as the indigestible ingredients can induce compositional or metabolic improvement to the gut microbiota, thereby improving gut health and giving rise to the production of short-chain fatty acids (SCFAs) to elicit metabolic effects on obesity. In this review, the role NDOs play in obesity intervention via modification of the gut microecology, as well as the physicochemical and physiological properties and industrial manufacture of NDOs, is discussed. Our goal is to provide a critical assessment of and stimulate comprehensive research into NDO use in obesity. Expected final online publication date for the, Volume 11 is March 25, 2020. Please see https://www.annualreviews.org/page/journal/pubdates for revised estimates.