Article Publish Status: FREE
Abstract Title:

Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis intumor-bearing mice.

Abstract Source:

Korean J Physiol Pharmacol. 2019 Nov ;23(6):501-508. Epub 2019 Oct 24. PMID: 31680772

Abstract Author(s):

Wen Cao, Kai Mo, Sijun Wei, Xiaobu Lan, Wenjuan Zhang, Weizhe Jiang

Article Affiliation:

Wen Cao


Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species ofand. The previous studies have revealed that RA had therapeutic effects on hepatocellular carcinoma (HCC) in the-xenograft models by inhibiting the inflammatory cytokines and NF-κB p65 pathway in the tumor microenvironment. However, its molecular mechanisms of immunoregulation and pro-apoptotic effect in HCC have not been fully explored. In the present study, RA at 75, 150, and 300 mg/kg was given totumor-bearing mice via gavage once a day for 10 days. The results showed that RA can effectively inhibit the tumor growth through regulating the ratio of CD4/CD8and the secretion of interleukin (IL)-2 and interferon-γ, inhibiting the expressions of IL-6, IL-10 and signal transducer and activator of transcription 3, thereby up-regulatingandand down-regulating. The underlying mechanisms involved regulation of immune response and induction of HCC cell apoptosis. These results may provide a more comprehensive perspective to clarify the anti-tumor mechanism of RA in HCC.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.