Abstract Title:

Effects of walnuts consumption on vascular endothelial function in humans: A systematic review and meta-analysis of randomized controlled trials.

Abstract Source:

Clin Nutr ESPEN. 2018 Dec ;28:52-58. Epub 2018 Sep 1. PMID: 30390893

Abstract Author(s):

Mohsen Mohammadi-Sartang, Nick Bellissimo, Julia O Totosy de Zepetnek, Hadi Bazyar, Marzieh Mahmoodi, Zohreh Mazloom

Article Affiliation:

Mohsen Mohammadi-Sartang


BACHGROUND AND AIMS: Endothelial dysfunction can promote atherosclerosis pathogenesis. The aim of the present meta-analysis was to determine the effects of walnut consumption on peripheral endothelial function (EF) in adults.

METHODS: PUBMED, MEDLINE and EMBASE were searched to identify studies up to August 2017. Eligible studies conducted randomized controlled trials (RCTs) on the effects of walnut consumption compared with a control on EF. Standard mean difference (SMD) and 95% confidence intervals (CI) were reported as summary statistics. Standard methods were used for assessment of heterogeneity, meta-regression, sensitivity analysis and publication bias.

RESULTS: Five studies comprising a total of 323 subjects were included in the meta-analysis. The results showed a significant increase in EF after walnut consumption (SMD: 0.40%; 95% CI: 0.20 to 0.62; p < 0.001) with no evidence of heterogeneity across studies. Sensitivity analysis showed that the effect size was robust and not sensitive to any single study. Meta-regression did not indicate any significant association for an increase in EF after walnut consumption with dose of treatment, duration of treatment, or baseline EF.

CONCLUSION: The available evidence from RCTs suggests there may be a clinically relevant effect of walnut consumption on EF.

Study Type : Meta Analysis

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