Abstract Title:

Enhanced wound healing by an epigallocatechin gallate-incorporated collagen sponge in diabetic mice.

Abstract Source:

Wound Repair Regen. 2008 Sep-Oct;16(5):714-20. PMID: 19128267

Abstract Author(s):

HakHee Kim, Takeshi Kawazoe, Dong-Wook Han, Kazuaki Matsumara, Shigehiko Suzuki, Sadami Tsutsumi, Suong-Hyu Hyon

Article Affiliation:

Department of Medical Simulation Engineering, Research Center for Nano Medical Engineering, Institute for Frontier Medical Science, Kyoto University,53 Kawahara-cho,Shogoin, Sakyo-ku, Kyoto, Japan.


Epigallocatechin-3-O-gallate (EGCG), the major polyphenolic compound present in green tea, has potent anti-oxidant and free radical-scavenging activities. In this study, various concentrations (10, 100, and 1,000 ppm) of EGCG were incorporated into a collagen sponge (CS) in order to investigate its healing effects on full-thickness wounds created in type 2 diabetic mice. After 14 days, the residual wound size of the mice treated with 10 ppm EGCG-incorporated collagen sponge (E-CS) decreased significantly faster than that of the other mice. Moreover, significant increases in the degree of reepithelialization, the thickness of the granulation tissue, and the density of the capillaries were also histologically observed in the wound sites exposed to 10 ppm E-CS in comparison with the others. Furthermore, 10 ppm E-CS resulted in significant increases in the immunoreactivity of Ki-67 (reepithelialization at the wound site), CD31 (formation of blood vessels), and alpha-smooth muscle actin (the induction of myofibroblasts across the dermis). These results suggest that a CS incorporated with EGCG at low concentrations can enhance wound healing in diabetic mice by accelerating reepithelialization and angiogenesis as well as improving the cellular reorganization of granulation tissue by triggering the activity of myofibroblasts.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.