Abstract Title:

Hypolipidemic effect of flavonoids from Solanum melongena.

Abstract Source:

Plant Foods Hum Nutr. 1997;51(4):321-30. PMID: 9650725

Abstract Author(s):

S Sudheesh, G Presannakumar, S Vijayakumar, N R Vijayalakshmi

Article Affiliation:

Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, India.


Flavonoids extracted from the fruits of Solanum melongena (Brinjal) orally administered at a dose of 1 mg/100 g BW/day showed significant hypolipidemic action in normal and cholesterol fed rats. HMG CoA reductase activity was found to be enhanced, while activities of glucose-6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. Activities of lipoprotein lipase and plasma LCAT showed significant enhancement. A significant increase in the concentrations of hepatic and fecal bile acids and fecal neutral sterols was also observed indicating a higher rate of degradation of cholesterol.

Study Type : Animal Study

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