Abstract Title:

Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes.

Abstract Source:

Atherosclerosis. 2007 Mar;191(1):162-7. Epub 2006 Apr 17. PMID: 16616147

Abstract Author(s):

Tomoya Mita, Hirotaka Watada, Takeshi Ogihara, Takashi Nomiyama, Osamu Ogawa, Junichiro Kinoshita, Tomoaki Shimizu, Takahisa Hirose, Yasushi Tanaka, Ryuzo Kawamori


To investigate the effect of highly purified eicosapentaenoic acid (EPA) on the progression of diabetic macroangiopathy, we performed an open-label randomized prospective trial. A total of 81 Japanese type 2 diabetes were randomly assigned to the EPA (1800 mg/day) treated group or the control group. Carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) were evaluated before and after treatment in both groups. Sixty patients (EPA group, n=30; control group, n=30) completed this study. During the study period of 2.1+/-0.2 years, the mean IMT and max IMT of the EPA treated group showed a significant annual decrease compared with that of the control group (mean IMT, -0.029+/-0.112 mm versus 0.016+/-0.109 mm, respectively, P=0.029; max IMT, -0.084+/-0.113 mm versus -0.005+/-0.108 mm, respectively, P=0.0008). The baPWV was also improved significantly in the EPA treated group compared with the control group (-22.1+/-127.9 cm/s versus 62.3+/-223 cm/s, respectively, P=0.021). Multiple regression analysis showed that the administration of EPA was a significant and independent factor associated with an annual improvement of mean IMT (R2=0.067). In summary, this is the first demonstration that administration of purified EPA improves the carotid IMT and the baPWV in patients with type 2 diabetes.

Study Type : Human Study

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