Abstract Title:

Tumor cell specific toxicity of Inula helenium extracts.

Abstract Source:

Complement Ther Clin Pract. 2010 May;16(2):81-5. Epub 2009 Aug 19. PMID: 16912983

Abstract Author(s):

David C Dorn, Maja Alexenizer, Jan G Hengstler, August Dorn


The aim of the research program was to identify botanical extracts with antineoplastic activity. In this respect extracts prepared from Inula helenium roots showed a remarkable activity. As evidenced by the MTT assay, the Inula helenium extract revealed a highly selective toxicity toward four different tumor cell lines (HT-29, MCF-7, Capan-2 and G1), but a much lower toxicity against healthy human peripheral blood lymphocytes (PBLs) from two donors. The extract-induced death of tumor cells was studied extensively by electron microscopy. There was a remarkable similarity of morphological alterations observed in the four cell lines: patchy chromatin condensations, cytoplasmic vesiculation, swelling and rupture of mitochondria. The morphology of cellular breakdown bore more resemblance to necrotic than to apoptotic cell death, which was supported by the failure to mark early apoptotic events by Annexin V. It has been pointed out recently that compounds inducing cell death with necrotic-like morphology could be very beneficial in cases where cancerous cells have gained resistance to apoptosis. In this context, the remarkable difference in cytotoxicity exerted by the Inula helenium extract, which was over 100-times higher in the tumor cell lines than in the PBLs, makes the extract an excellent candidate for further anticancerous investigations, especially since the Inula helenium extract was not mutagenic in the Ames test.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.