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Article Publish Status: FREE
Abstract Title:

Electromagnetic fields alter the motility of metastatic breast cancer cells.

Abstract Source:

Commun Biol. 2019 ;2:303. Epub 2019 Aug 8. PMID: 31428691

Abstract Author(s):

Ayush Arpit Garg, Travis H Jones, Sarah M Moss, Sanjay Mishra, Kirti Kaul, Dinesh K Ahirwar, Jessica Ferree, Prabhat Kumar, Deepa Subramaniam, Ramesh K Ganju, Vish V Subramaniam, Jonathan W Song

Article Affiliation:

Ayush Arpit Garg

Abstract:

Interactions between cells and their environment influence key physiologic processes such as their propensity to migrate. However, directed migration controlled by extrinsically applied electrical signals is poorly understood. Using a novel microfluidic platform, we found that metastatic breast cancer cells sense and respond to the net direction of weak (∼100 µV cm), asymmetric, non-contact induced Electric Fields (iEFs). iEFs inhibited EGFR (Epidermal Growth Factor Receptor) activation, prevented formation of actin-rich filopodia, and hindered the motility of EGF-treated breast cancer cells. The directional effects of iEFs were nullified by inhibition of Akt phosphorylation. Moreover, iEFs in combination with Akt inhibitor reduced EGF-promoted motility below the level of untreated controls. These results represent a step towards isolating the coupling mechanism between cell motility and iEFs, provide valuable insights into how iEFs target multiple diverging cancer cell signaling mechanisms, and demonstrate that electrical signals are a fundamental regulator of cancer cell migration.

Study Type : Human In Vitro

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