Abstract Title:

Electroacupuncture alleviates multifidus muscle injury by modulating mitochondrial function and Cauptake.

Abstract Source:

Anat Rec (Hoboken). 2022 Mar 2. Epub 2022 Mar 2. PMID: 35235712

Abstract Author(s):

Xia Li, Jun Zhao, Qiaoqiao Lv, Yuan Tian, Li Zhang, Tong Liu

Article Affiliation:

Xia Li


Multifidus muscles maintain the stability of the lumbar spine and play a crucial role in the pathogenesis of nonspecific lower back pain. Previous studies have shown that electroacupuncture (EA) can relieve the symptoms of low back pain and reduce injury to the lumbar multifidus muscles. In this study, a rat model of lumbar multifidus muscle injury was established by 0.05% bupivacaine injection and subsequently treated with EA at bilateral "Weizhong" (BL40) acupoints. Disruption of the function and structure of multifidus muscles, increased cytosolic Cain multifidus myocytes, and reduced mitochondrial fission and ATP production were observed in the model group. Additionally, increased expression of the mitochondrial calcium uniporter (MCU) promoted mitochondrial reuptake of Ca, reversing the excessive increase in cytoplasmic Ca. However, the excessive increase in MCU not only aggravated the increased cytoplasmic Cabut also decreased the expression of the mitochondrial division proteins dynamin-related protein 1 (Drp1) and mitochondrial fission factor (MFF). EA inhibited the overexpression of MCU, promoted mitochondrial reuptake of Ca, and reversed cytosolic Caoverload. Furthermore, EA regulated the expression of the mitochondrial fission proteins Drp1 and MFF and promoted the production of ATP, helping the recovery of mitochondrial function after multifidus injury. Therefore, EA can protect against bupivacaine-induced mitochondrial dysfunction, possibly by attenuating MCU overexpression in the inner mitochondrial membrane and reducing Caoverloading in muscle cells, thereby protecting mitochondrial function and maintaining the normal energy demand of muscle cells.

Study Type : Animal Study
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