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Article Publish Status: FREE
Abstract Title:

Electroacupuncture attenuates surgical pain-induced delirium-like behavior in miceremodeling gut microbiota and dendritic spine.

Abstract Source:

Front Immunol. 2022 ;13:955581. Epub 2022 Aug 8. PMID: 36003380

Abstract Author(s):

Liuyue Yang, Weihua Ding, Yuanlin Dong, Cynthia Chen, Yanru Zeng, Zhangjie Jiang, Shuyuan Gan, Zerong You, Yilin Zhao, Yiying Zhang, Xinghua Ren, Shiyu Wang, Jiajia Dai, Zhong Chen, Shengmei Zhu, Lucy Chen, Shiqian Shen, Jianren Mao, Zhongcong Xie

Article Affiliation:

Liuyue Yang

Abstract:

Surgical pain is associated with delirium in patients, and acupuncture can treat pain. However, whether electroacupuncture can attenuate the surgical pain-associated deliriumthe gut-brain axis remains unknown. Leveraging a mouse model of foot incision-induced surgical pain and delirium-like behavior, we found that electroacupuncture stimulation at specific acupoints (e.g., DU20+KI1) attenuated both surgical pain and delirium-like behavior in mice. Mechanistically, mice with incision-induced surgical pain and delirium-like behavior showed gut microbiota imbalance, microglia activation in the spinal cord, somatosensory cortex, and hippocampus, as well as an enhanced dendritic spine elimination in cortex revealed by two-photon imaging. The electroacupuncture regimen that alleviated surgical pain and delirium-like behavior in mice also effectively restored the gut microbiota balance, prevented the microglia activation, and reversed the dendritic spine elimination. These data demonstrated a potentially important gut-brain interactive mechanism underlying the surgical pain-induced delirium in mice. Pending further studies, these findings revealed a possible therapeutic approach in preventing and/or treating postoperative delirium by using perioperative electroacupuncture stimulation in patients.

Study Type : Animal Study

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