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Article Publish Status: FREE
Abstract Title:

β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis.

Abstract Source:

Biomedicines. 2021 Jun 22 ;9(7). Epub 2021 Jun 22. PMID: 34206511

Abstract Author(s):

Yingyu Zhou, Wanyi Qiu, Yimei Wang, Rong Wang, Tomohiro Takano, Xuyang Li, Zhangliang Zhu, Haruyo Nakajima-Adachi, Masaru Tanokura, Satoshi Hachimura, Takuya Miyakawa

Article Affiliation:

Yingyu Zhou

Abstract:

As a kind of metabolically triggered inflammation, obesity influences the interplay between the central nervous system and the enteral environment. The present study showed thatβ-elemene, which is contained in various plant substances, had effects on recovering the changes in metabolites occurring in high-fat diet (HFD)-induced obese C57BL/6 male mice brains, especially in the prefrontal cortex (PFC) and hippocampus (HIP). β-elemene also partially reversed HFD-induced changes in the composition and contents of mouse gut bacteria. Furthermore, we evaluated the interaction between cerebral metabolites and intestinal microbiota via Pearson correlations. The prediction results suggested thatwere possibly controlled by neuron integrity, cerebral inflammation, and neurotransmitters, andin mouse intestines might be related to cerebral aerobic respiration and the glucose cycle. Such results also implied thatprobably affected cerebral energy metabolism. These findings suggested thatβ-elemene has regulatory effects on the imbalanced microbiota-gut-brain axis caused by obesity and, therefore, would contribute to the future study in on the interplay between cerebral metabolites from different brain regions and the intestinal microbiota of mice.

Study Type : Animal Study

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