Abstract Title:

[Intestinal permeability in Crohn's disease and effects of elemental dietary therapy].

Abstract Source:

Nippon Shokakibyo Gakkai Zasshi. 2001 Jun;98(6):636-43. PMID: 11436280

Abstract Author(s):

M Iwata, H Nakano, Y Matsuura, M Nagasaka, M Misawa, S Mizuta, I Ito, T Saito, T Ito, M Hokama, M Kamiya, R Hobara, M Watanabe, K Takahama

Article Affiliation:

Department of Internal Medicine and Gastroenterology, Fujita Health University.


Enteral intake of non-metabolic monosacharide and disaccharide, followed by measurement of the urinary excretion ratio of the two, is a method used to investigate intestinal permeability. L/R ratio (lactulose/1-rhamnose urinary excretion ratio) is considered an indicator of permeability of the small intestine. An increased L/R ratio is caused by mucosal disorders of the small intestine. The L/R ratio in all patients (n = 92) with Crohn's disease was 0.079 +/- 0.081 (mean +/- S.D.), which was significantly higher than the value in normal controls (0.027 +/- 0.009, n = 20, p<0.05). In 39 patients with Crohn's disease, we assessed intestinal permeability before after treatment with an elemental diet, and during remission. The L/R ratio was 0.120 +/- 0.092, before treatment and 0.065 +/- 0.097 after treatment (p<0.05), showing increased intestinal permeability before elemental dietary treatment. During remission, the L/R ratio was 0.035 +/- 0.028; this did not differ significantly from the value obtained after treatment. We conclude that intestinal permeability is useful for investigating disease activity in patients with Crohn's disease.

Study Type : Human Study

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