Abstract Title:

Elevated Serum Lipid Peroxidation and Reduced Vitamin C and Trace Element Concentrations Are Correlated With Epilepsy.

Abstract Source:

Clin EEG Neurosci. 2018 May 1:1550059418772755. Epub 2018 May 1. PMID: 29788779

Abstract Author(s):

Abhijit Das, Md Shahid Sarwar, Md Shohel Hossain, Palash Karmakar, Mohammad Safiqul Islam, Mohammad Enayet Hussain, Sujan Banik

Article Affiliation:

Abhijit Das


BACKGROUND: Epilepsy is one of the chronic and heterogeneous epidemic neurological disorders leading to substantial mortality. The aim of the present study was to investigate the serum levels of malondialdehyde (MDA), vitamin C, and trace elements namely zinc (Zn), copper (Cu), and manganese (Mn) in epileptic patients of Bangladesh and to establish if there are any pathophysiological correlations.

METHODS: This was a case-control study with 40 generalized epileptic patients and 40 healthy subjects as controls. Epilepsy was determined by the presence of seizure events with an abnormal electroencephalography and magnetic resonance imaging report of brain.

RESULTS: Anthropometric parameters highlighted that age is a major risk factor of epilepsy and men are more prone to epilepsy than women. Blood serum analysis demonstrated significantly ( P<.001) higher values of MDA and lower level of vitamin C in the patient group (4.41± 0.76 μmol/mL and 18.31 ± 0.84 μmol/L, respectively) compared with control (1.81 ± 0.70 μmol/mL and 29.72 ± 1.06 μmol/L, respectively). Pearson's correlation analysis revealed a negative correlation between the serum level of MDA and vitamin C for both patient ( r = -0.023, P = .887) and control group ( r = -0.142, P = .383). This study also revealed that the trace elements (Zn, Cu) were significantly ( P<.05) lower in epileptics (68.32± 4.59 and 50.81 ± 2.54 μg/dL, respectively) where the level of Mn in patients (187.71 ± 9.04 μg/dL) was almost similar to that of the control group ( P>.05). The univariate analysis demonstrated that zinc<70μg/dL (odds ratio = 3.56, P<.05) and copper<50μg/dL were associated (odds ratio = 14.73, P<.001) with an increased risk of epilepsy. Establishment of interelement relationship strongly supported that there was a disturbance in the element homeostasis of epileptic patients.

CONCLUSIONS: The study results strengthen the role of lipid peroxidation, antioxidants and trace elements in the pathogenesis and warrant larger studies to investigate the association of these biochemical parameters with epilepsy.

Study Type : Human Study

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