Article Publish Status: FREE
Abstract Title:

Ellagic acid attenuates post-cerebral ischemia and reperfusion behavioral deficits by decreasing brain tissue inflammation in rats.

Abstract Source:

Iran J Basic Med Sci. 2020 May ;23(5):645-653. PMID: 32742603

Abstract Author(s):

Khadijeh Hassonizadeh Falahieh, Alireza Sarkaki, Mohammadamin Edalatmanesh, Mohammad Kazem Gharib Naseri, Yaghoob Farbood

Article Affiliation:

Khadijeh Hassonizadeh Falahieh


Objectives: Cerebral ischemia/reperfusion (I/R) causes brain inflammation that ultimately causes long time brain function disturbances. We aimed to evaluate the effect of ellagic acid (EA) on anxiety, depression, locomotion behaviors, blood-brain barrier (BBB) permeability, brain edema, and inflammation in male rats with cerebral I/R.

Materials and Methods: Sixty male Wistar rats (250-300 g) divided into 6 groups randomly with 10 in each: 1) Sham+Veh; rats submitted to the surgery without any I/R and received vehicle (10% DMSO in normal saline 5 ml/kg, gavages). 2) I/R+Veh; 3-5) I/R+EA; I/R rats received 50, 75 and 100 EA mg/kg, by gavages 3 times daily for one week. The cerebral I/R injury was induced by clamping the bilateral common carotid arteries for 20 minutes followed by reperfusion. Behaviors were tested one week after treatment, and brain tissue cytokines were measured by special ELISA kits.

Results: Cerebral I/R disrupted BBB function (<0.001), increased brain water content (<0.01), anxiety-like (<0.001), depression-like (<0.001) behaviors and cytokines in the brain tissue (<0.001), while decreased locomotion and exploratory behaviors significantly (<0.01 and<0.001, respectively). Administration of EA (100 mg/kg but not other doses) could improve post-ischemic complications such as clinical signs (<0.01), BBB function (<0.001), brain edema (<0.01), brain tissue cytokines (<0.001), locomotion and exploratory behaviors significantly (<0.05 and<0.001, respectively).

Conclusion: The results suggest that EA could be a potential therapeutic agent against cerebral I/R, possibly through its intertwined anti-inflammatory effects. Further research is required to investigate the involved mechanisms in details.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.