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Abstract Title:

Emodin modulates gut microbial community and triggers intestinal immunity.

Abstract Source:

J Sci Food Agric. 2022 Sep 11. Epub 2022 Sep 11. PMID: 36088620

Abstract Author(s):

Humphrey A Mabwi, Hee Ju Lee, Emmanuel Hitayezu, Intan Rizki Mauliasari, Cheol-Ho Pan, Kilaza Samson Mwaikono, Erick V G Komba, Choong-Gu Lee, Kwang Hyun Cha

Article Affiliation:

Humphrey A Mabwi

Abstract:

BACKGROUND: The gut microbiota (GM) plays an important role in human health and is being investigated as a possible target for new therapies. Although there are many studies showing that emodin can improve host health, emodin-GM studies are scarce. Here, the effects of emodin on the GM were investigated in vitro and in vivo.

RESULTS: In vitro single bacteria cultivation showed that emodin stimulated the growth of beneficial bacteria Akkermansia, Clostridium, Roseburia, and Ruminococcus but inhibited major gut enterotypes (Bacteroides and Prevotella). Microbial community analysis from a synthetic gut microbiome model through co-culture indicated the consistent GM change by emodin. Interestingly, emodin stimulated Clostridium and Ruminococcus (which are related to Roseburia and Faecalibacterium) in a mice experiment and induced anti-inflammatory immune cells, which may correlate with its impact on specific gut bacteria.

CONCLUSION: Emodin (i) showed similar GM changes in monoculture, co-culture, and in an in vivo mice experiment and (ii) simulated regulatory T-cell immune responses in vivo. This suggest that emodin may be used to modulate the GM and improve health.© 2022 Society of Chemical Industry.

Study Type : In Vitro Study

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