Article Publish Status: FREE
Abstract Title:

Encapsulation of Antihypertensive Peptides from Whey Proteins and Their Releasing in Gastrointestinal Conditions.

Abstract Source:

Biomolecules. 2019 04 27 ;9(5). Epub 2019 Apr 27. PMID: 31035630

Abstract Author(s):

Yolanda Alvarado, Claudia Muro, Javier Illescas, María Del Carmen Díaz, Francisco Riera

Article Affiliation:

Yolanda Alvarado


Antihypertensive peptide fraction from whey protein hydrolysate<3 kDa (measured as angiotensin-converting enzyme (ACE) activity %) was isolated and encapsulated into three composite materials: alginate-collagen, alginate Arabic gum, and alginate-gelatin. The release behavior of peptide fraction from capsules was analyzed according to the encapsulation material efficiency, the characteristics of the capsules, and the released antihypertensive peptides during gastrointestinal digestion. The highest encapsulation efficiency was found in capsules of alginate Arabic gum (95%). In this case, the released peptides incremented their ACE activity (85%) after the digestion process, with respect to the initial ACE activity (74%). Whey antihypertensive fraction revealed five peptide sequences; however, other amino acid sequences were released from digested capsules. Protein databases confirmed some antihypertensive sequences indicating the peptides content fromβ-Lg and α-La. Consequently, new peptides could be revealed from whey antihypertensive fraction.

Study Type : In Vitro Study

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