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Article Publish Status: FREE
Abstract Title:

Enhanced Anti-Inflammatory Effects of Silibinin and Capsaicin Combination in Lipopolysaccharide-Induced RAW264.7 Cells by Inhibiting NF-κB and MAPK Activation.

Abstract Source:

Front Chem. 2022 ;10:934541. Epub 2022 Jun 30. PMID: 35844639

Abstract Author(s):

Yingying Zheng, Jie Chen, Xiaozheng Wu, Xin Zhang, Chunmei Hu, Yu Kang, Jing Lin, Jiamin Li, Yuechang Huang, Xingmin Zhang, Chen Li

Article Affiliation:

Yingying Zheng

Abstract:

Silibinin and capsaicin both are natural product molecules with diverse biological activities. In this article, we investigated the anti-inflammatory effects of silibinin combined with capsaicin in lipopolysaccharide (LPS)-induced RAW264.7 cells. The results showed that silibinin combined with capsaicin strongly inhibited LPS-induced nitric oxide (NO), tumor necrosis factor-α (TNF-α), Interleukin-6 (IL-6), and COX-2. Moreover, silibinin combined with capsaicin potently inhibited nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. The results of the present study indicate that silibinin combined with capsaicin effectively inhibits inflammation.

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