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Abstract Title:

Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation-loading fisetin against acetaminophen-induced liver injury.

Abstract Source:

Nanomedicine (Lond). 2021 Oct 11. Epub 2021 Oct 11. PMID: 34632809

Abstract Author(s):

Hui Yang, Qilong Cao, Zhixin Yuan, Xianggen Wu, Mengshuang Li

Article Affiliation:

Hui Yang

Abstract:

To evaluate the feasibility of using dipotassium glycyrrhizinate (DG) as a nanocarrier-loading fisetin (FIT) with strengthened treatment efficacies against liver injury induced by acetaminophen overdose.DG-FIT was prepared, and its efficacy against liver injury induced by acetaminophen overdose was evaluated.DG-FIT was successfully fabricated with excellent physicochemical properties. DG-FIT could be easily dissolved in water to form a clear micelle solution with high FIT encapsulation efficiency. FIT in DG-FIT exhibited a dramatically improved aqueous solubility. DG-FIT improved intestinal permeation. Regarding efficacies, DG-FIT exhibited significant effect against acetaminophen overdose by suppressing oxidative stress and proinflammatory cytokines involved.DG-FIT formulation possibly represents a promising method for strengthening the efficacy of FIT against acetaminophen-induced liver injury.

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