Abstract Title:

Enhancing activity of artesunate against breast cancer cells via induced-apoptosis pathway by loading into lipid carriers.

Abstract Source:

Artif Cells Nanomed Biotechnol. 2016 Dec ;44(8):1979-1987. Epub 2016 Jan 11. PMID: 26754823

Abstract Author(s):

Tuan Hiep Tran, Anh Ngoc Nguyen, Jong Oh Kim, Chul Soon Yong, Chien Ngoc Nguyen

Article Affiliation:

Tuan Hiep Tran


Artesunate-loaded nanostructured lipid carriers (ART-NLCs) were prepared by hot homogenization followed by ultrasonication technique. The optimized ART-NLC demonstrated a particle size of 117.5 ± 6.1 nm, with good stability regarding zeta-potential of  -19.47 ± 0.9 mV and drug entrapment efficiency of 92.93 ± 1.47%. ART-NLC showed good cellular uptake in breast cancer cells, which was confirmed by confocal laser scanning microscopy (CLSM) and flow cytometry analysis. The significantly higher in vitro cytotoxicity of ART-NLCs against human breast cancer MCF-7, MDA-MB-231 cells as compared with the free ART was recorded.  Hoechst 33342 staining indicated that ART-NLC induced higher apoptosis rates in MCF-7 as well as MDA-MB-231cells than free ART.

Study Type : In Vitro Study

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