Abstract Title:

Blueberry anthocyanins-enriched extracts attenuate the cyclophosphamide-induced lung toxicity.

Abstract Source:

Chem Biol Interact. 2014 Oct 16 ;222C:106-111. Epub 2014 Oct 16. PMID: 25451569

Abstract Author(s):

Dehong Tan, Yunen Liu, Lin Shi, Bin Li, Ling Liu, Bing Bai, Xianjun Meng, Mingxiao Hou, Xiaoxu Liu, Lei Sheng, Xinyue Luo

Article Affiliation:

Dehong Tan


The influence of blueberry anthocyanins-enriched extracts (BAE) on cyclophosphamide (CTX)-induced lung damage was investigated. BAE (20 and 80mg/kg/d) were orally dosed to rats 7d both before and after CTX administration (100mg/kg, intraperitoneal injection, single dose). The results showed CTX treatment induced obvious pathological pulmonary injury with raised injury score and lung/body weight ratio. In CTX group, the activity of lysosomal proteases, lung permeability and the number of neutrophil infiltrates all elevated. On the other hand, claudin-4 and zonula occluden-1 protein levels decreased. And also changes of oxidative stress and inflammatory cytokines parameters together with nuclear factor-κB activation were shown. Improvement of all above-mentioned physiological and biochemical parameters was exhibited in BAE groups, with a dose-dependent manner. In conclusion, BAE attenuate the CTX-induced lung toxicity, antioxidant and anti-inflammatory characteristics are involved in the protective mechanism of BAE.

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