ent-kaurane diterpenoids with neuroprotective properties from corn silk. - GreenMedInfo Summary
ent-Kaurane Diterpenoids with Neuroprotective Properties from Corn Silk ( Zea mays).
J Nat Prod. 2018 05 25 ;81(5):1225-1234. Epub 2018 May 15. PMID: 29762032
Thirteen new ent-kaurane diterpenoids, stigmaydenes A-M (1-13), together with two known compounds (14, 15), were isolated from the crude extract of corn silk ( Zea mays). The structures of the compounds were confirmed by comprehensive spectroscopic analyses. The absolute configuration of compound 1 was defined by single-crystal X-ray diffraction. The absolute configurations of the compounds were also confirmed by comparison of experimental and calculated specific rotations. The compounds were evaluated for their neuroprotective effects against HO-induced SH-SY5Y cell injury, and compound 8 was active at 100μM, as determined by flow cytometry (annexin V-FITC/PI staining) and Hoechst 33258 staining. The results suggested that compound 8 could protect neuronal cells from HO-induced injury by inhibiting apoptosis in SH-SY5Y cells.