Abstract Title:

Ectopic calcification of rat aortas and kidneys is reduced with n-3 fatty acid supplementation.

Abstract Source:

Prostaglandins Leukot Essent Fatty Acids. 1998 Sep;59(3):221-7. PMID: 9844996

Abstract Author(s):

C K Schlemmer, H Coetzer, N Claassen, M C Kruger, C Rademeyer, L van Jaarsveld, C M Smuts


Supplementation with essential fatty acids has been shown to prevent the experimentally induced ectopic calcification of the kidneys known as nephrocalcinosis. Male Sprague-Dawley rats were fed a semi-synthetic diet supplemented with different essential fatty acids while being injected for a period of 10 days with calcium glubionate. After 3 weeks their kidneys and aorta were removed and the respective calcium content measured compared to the control, saline injected animals. Lipoic acid-EPA, fish oil (EPA rich) as well as the EPA monoester reduced the calcium concentration of both the kidneys and the aorta towards control values. Lipoic-EPA was the best absorbed of the three compounds and its combination of anti-oxidant together with EPA lowered the calcium content of both the aortas and the kidneys.

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