Abstract Title:

(-)-Epigallocatechin-3-gallate increases cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus in adult mice.

Abstract Source:

Phytother Res. 2010 Jul ;24(7):1065-70. PMID: 20013823

Abstract Author(s):

Ki-Yeon Yoo, Jung Hoon Choi, In Koo Hwang, Choong Hyun Lee, Soon Ok Lee, Sag-Myung Han, Hyung-Cheul Shin, Il-Jun Kang, Moo-Ho Won

Article Affiliation:

Ki-Yeon Yoo


Neurogenesis is regulated by several factors such as age, stress and pharmacological agents. We observed the effects of (-)-epigallocatechin-3-gallate (EGCG), a major catechin of green tea, on neurogenesis in mice. The animals were orally administered EGCG for 4 weeks. Brain sections were stained using a marker for cell proliferation (Ki67 and BrdU) and neuroblasts (doublecortin, DCX). In all groups, Ki67, BrdU and DCX immunoreaction were observed in the subgranular zone of the dentate gyrus. Oral administration of EGCG significantly increased the number of Ki67-, BrdU- and DCX-immunoreactive cells as well as BrdU/DCX-colabled cells in the subgranular zone when compared to those in the vehicle-treated group. These results indicate that oral administration of EGCG can enhance cell proliferation and increase the number of neuroblasts in mice hippocampal dentate gyrus.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Regenerative : CK(408) : AC(172)

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