n/a
Article Publish Status: FREE
Abstract Title:

Epigenetic Factors in Late-Onset Alzheimer's Disease:andGene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins.

Abstract Source:

Int J Mol Sci. 2019 Jan 14 ;20(2). Epub 2019 Jan 14. PMID: 30646578

Abstract Author(s):

Gustavo C Román, Oscar Mancera-Páez, Camilo Bernal

Article Affiliation:

Gustavo C Román

Abstract:

DNA methylation and other epigenetic factors are important in the pathogenesis of late-onset Alzheimer's disease (LOAD). Methylenetetrahydrofolate reductase () gene mutations occur in most elderly patients with memory loss. MTHFR is critical for production of S-adenosyl-l-methionine (SAM), the principal methyl donor. A common mutation (1364T/T) of the cystathionine-γ-lyase () gene affects the enzyme that converts cystathionine to cysteine in the transsulfuration pathway causing plasma elevation of total homocysteine (tHcy) or hyperhomocysteinemia-a strong and independent risk factor for cognitive loss and AD. Other causes of hyperhomocysteinemia include aging, nutritional factors, and deficiencies of B vitamins. We emphasize the importance of supplementing vitamin B(methylcobalamin), vitamin B₉ (folic acid), vitamin B₆ (pyridoxine), and SAM to patients in early stages of LOAD.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.