Article Publish Status: FREE
Abstract Title:

Epigenetic underpinnings of developmental immunotoxicity and autoimmune disease.

Abstract Source:

Curr Opin Toxicol. 2018 Aug ;10:23-30. Epub 2017 Dec 1. PMID: 30613805

Abstract Author(s):

Sarah J Blossom, Kathleen M Gilbert

Article Affiliation:

Sarah J Blossom


The concordance rate for developing autoimmune disease in identical twins is around 50% demonstrating that gene and environmental interactions contribute to disease etiology. The environmental contribution to autoimmune disease is a wide-ranging concept including exposure to immunotoxic environmental chemicals. Because the immune system is immature during development suggests that adult-onset autoimmunity may originate when the immune system is particularly sensitive. Among the pollutants most closely associated with inflammation and/or autoimmunity include Bisphenol-A, mercury, TCDD, and trichloroethylene. These toxicants have been shown to impart epigenetic changes (e.g., DNA methylation) that may alter immune function and promote autoreactivity. Here we review these autoimmune-promoting toxicants and their relation to immune cell epigenetics both in terms of adult and developmental exposure.

Study Type : Review

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