Abstract Title:

Sedative and anticonvulsant effects of hydroalcoholic extract of Equisetum arvense.

Abstract Source:

Fitoterapia. 2005 Sep;76(6):508-13. PMID: 15972249

Abstract Author(s):

J G Dos Santos, M M Blanco, F H M Do Monte, M Russi, V M N B Lanziotti, L K A M Leal, G M Cunha


Full Citation: "The hydroalcoholic extract of Equisetum arvense (HAE) tested at the doses of 200 and 400 mg/kg showed a significant activity on the open-field, enhanced the number of falls in the rota-rod reducing the time of permanence in the bar and increased the sleeping time (46% and 74%) in the barbiturate-induced sleeping time. In the pentylenetetrazole-seizure, it increased the first convulsion latency, diminished the severity of convulsions, reduced the percentage of animals which developed convulsion (50% and 25%) and protected animals from death. On the contrary, in the elevated plus maze, the doses 50, 100 and 150 mg/kg did not affect the evaluated parameters. Thus, HAE presented anticonvulsant and sedative effects. Phytochemical analysis detected the presence of tannins, saponins, sterols and flavonoids."

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