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Abstract Title:

Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle.

Abstract Source:

Cancer Chemother Pharmacol. 2016 Dec ;78(6):1143-1150. Epub 2016 Oct 20. PMID: 27766389

Abstract Author(s):

Ziyou Wang, Hua Zhang, Jiahui Zhou, Xiangning Zhang, Liyong Chen, Kangxing Chen, Zunnan Huang

Article Affiliation:

Ziyou Wang

Abstract:

Hepatocellular carcinoma is a lethal cancer with high recurrence ratio and lacks effective therapeutics. In the past few years, it has been reported that increased intake of vegetables and fruits could reduce the cancer incidence, which suggests dietary agents might possess anticancer effects. Eriocitrin is a flavonoid isolated from lemon, which is known as a strong antioxidant agent. We here for the first time demonstrated that eriocitrin could inhibit the proliferation of hepatocellular carcinoma cell lines by arresting cell cycle in S phase through up-regulation of p53, cyclin A, cyclin D3 and CDK6. Furthermore, we found that eriocitrin could trigger apoptosis by activating mitochondria-involved intrinsic signaling pathway. Thus, eriocitrin might be regarded as a potential chemopreventive natural product to inhibit the early malignant transformation of hepatocellular carcinoma.

Study Type : Review

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Sayer Ji
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