Eruca sativa meal against diabetic neuropathic pain: An H2S-mediated effect of glucoerucin. - GreenMedInfo Summary
Meal against Diabetic Neuropathic Pain: An HS-Mediated Effect of Glucoerucin.
Molecules. 2019 08 19 ;24(16). Epub 2019 Aug 19. PMID: 31430978
The management of pain in patients affected by diabetic neuropathy still represents an unmet therapeutic need. Recent data highlighted the pain-relieving efficacy of glucosinolates deriving from Brassicaceae. The purpose of this study was to evaluate the anti-hyperalgesic efficacy of Eruca sativa defatted seed meal, along with its main glucosinolate, glucoerucin (GER), on diabetic neuropathic pain induced in mice by streptozotocin (STZ). The mechanism of action was also investigated. Hypersensitivity was assessed by paw pressure and cold plate tests after the acute administration of the compounds. Once bio-activated by myrosinase, both E. sativa defatted meal (1 g kgp.o.) and GER (100µmol kgp.o., equimolar to meal content) showed a dose-dependent pain-relieving effect in STZ-diabetic mice, but the meal was more effective than the glucosinolate. The co-administration with HS scavengers abolished the pain relief mediated by bothmeal and GER. Their effect was also prevented by selectively blocking Kv7 potassium channels. Repeated treatments with E. sativa meal did not induce tolerance to the anti-hypersensitive effect. In conclusion,meal can be suggested as a new nutraceutical tool for pain relief in patients with diabetic neuropathy.