Abstract Title:

Protection of cultured spinal motor neurons by estradiol.

Abstract Source:

Neuroreport. 2000 Nov 9;11(16):3493-7. PMID: 11095506

Abstract Author(s):

T Nakamizo, M Urushitani, R Inoue, A Shinohara, H Sawada, K Honda, T Kihara, A Akaike, S Shimohama

Article Affiliation:

Department of Neurology, Graduate School of Medicine, Kyoto University, Japan.

Abstract:

Estrogens have been reported to exert neuroprotection in the brain, but there have been no reports of such neuroprotection in spinal motor neurons, the neurons selectively involved in amyotrophic lateral sclerosis (ALS). In this study, we demonstrated that 17beta-estradiol and its biologically inactive stereoisomer, 17alpha-estradiol, prevented glutamate- and nitric oxide (NO)-induced selective motor neuronal death observed in primary cultures of the rat spinal cord. The dose of estradiols required for motor neuron protection was greatly reduced by co-administration with glutathione. The results of this study shows that estradiol protects spinal motor neurons from excitotoxic insults in vitro, and may have application as a treatment for ALS.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.