Article Publish Status: FREE
Abstract Title:

Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two-Stage Mouse Skin Carcinogenesis.

Abstract Source:

Evid Based Complement Alternat Med. 2014 ;2014:328684. Epub 2014 Mar 6. PMID: 24734106

Abstract Author(s):

Ken Yasukawa, Sakiko Okuda, Yasuhito Nobushi

Article Affiliation:

Ken Yasukawa


Ethanol extracts of gymnema (Gymnema sylvestre) leaves exhibited marked antitumour-promoting activity in an in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. From the active fraction of the ethanol extract of the gymnema leaves, three triterpenoids were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 µg/ear) in mice. The tested compounds showed marked anti-inflammatory effects, with a 50% inhibitory dose of 50-555 nmol/ear.

Study Type : Animal Study

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