Ethanol may inhibit thyroid function. - GreenMedInfo Summary

Abstract Title:

Effect of zinc supplementation on the status of thyroid hormones and Na, K, And Ca levels in blood following ethanol feeding.

Abstract Source:

Biol Trace Elem Res. 2011 May;140(2):208-14. Epub 2010 Apr 20. PMID: 20405336

Abstract Author(s):

R Pathak, D Dhawan, A Pathak

Article Affiliation:

Department of Physiology, Bhojia Dental College, Baddi, India. [email protected]


The influence of zinc (Zn) on the serum levels of triiodothyronine (T(3)), thyroxine (T(4)), thyroid-stimulating hormone (TSH) and sodium (Na), potassium (K), and calcium (Ca) was evaluated following ethanol toxicity to the rats. To achieve this, male Wistar rats (150-195 g) were given 3 ml of 30% ethanol orally, and zinc was given in the form of zinc sulfate (227 mg/l) in their drinking water daily for 8 weeks. Ethanol feeding resulted in a slight decrease in T(3) and T(4) levels and a significant increase in thyroid-stimulating hormone concentration, which may be due to the direct stimulatory effect of ethanol on thyroid. Interestingly, when zinc was given to these rats, all the above levels were brought quite close to their normal levels, thus indicating the positive role of zinc in thyroid hormone metabolism. Serum Zn and Ca levels were found to be reduced, but Na levels were raised upon ethanol feeding. Restoration of normal levels of these metals upon zinc supplementation to ethanol fed rats confirms that zinc has potential in alleviating some of the altered thyroid functions following ethanol administration.

Study Type : Animal Study
Additional Links
Problem Substances : Ethanol : CK(27) : AC(12)
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid : CK(139) : AC(34)

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