Evaluation of the antidiabetic and antilipaemic activities of the hydroalcoholic extract of phoenix dactylifera palm leaves and its fractions in alloxan-induced diabetic rats.
Malays J Med Sci. 2010 Oct ;17(4):4-13. PMID: 22135555
Seyyed Ali Mard
BACKGROUND: The antidiabetic and antilipaemic effects of Phoenix dactylifera leaf extract (PDE) and its fractions were investigated in various rat models.
METHODS: Diabetes was induced in male Wistar rats by alloxan monohydrate. Diabetic animals were randomly divided into 8 groups (1 diabetic control and 7 treated groups). Diabetic control animals received saline (5 mL/kg) orally, whereas the treatment groups received different doses of PDE (100, 200, and 400 mg/kg), PDE fractions (50, 100, and 200 mg/kg), or glibenclamide (4 mg/kg) orally once a day for 14 days. Blood was withdrawn for glucose determination on the 1(st), 6(th), 10(th), and 14(th) days. The rats were fasted overnight and then sacrificed on the 14(th) day; blood was collected for biochemical evaluation, including the levels of blood glucose, plasma insulin, serum triglyceride, and cholesterol.
RESULTS: Subacute administration of PDE or its fractions in alloxan-induced diabetic rats significantly reduced blood glucose (P<0.01). Water intake, serum triglyceride, and cholesterol also decreased in treated animals compared with the control group (P<0.01). Plasma insulin level increased in the treated groups relative to the control group (P<0.01).
CONCLUSION: The results suggested that PDE exhibits antidiabetic and antilipaemic effects in alloxan-induced diabetic rats.