Abstract Title:

Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat.

Abstract Source:

AANA J. 2015 Apr ;83(2):91-8. PMID: 26016167

Abstract Author(s):

Tomás Eduardo Ceremuga, Debra Valdivieso, Catherine Kenner, Amy Lucia, Keith Lathrop, Owen Stailey, Heather Bailey, Jonathan Criss, Jessica Linton, Jordan Fried, Andrew Taylor, Gina Padron, Arthur Don Johnson

Article Affiliation:

Tomás Eduardo Ceremuga


Herbal medication use continues to rise and interactions with existing medications propose risks and may have significant effects and consequences on the administration of anesthesia. The purpose of this study was to investigate the anxiolytic and antidepressant effects of asiatic acid and its potential modulation of theγ-aminobutyric acid (GABAA) receptor. Fifty-five male Sprague Dawley rats were divided into 5 groups: vehicle (DMSO), asiatic acid (AA), midazolam, or a combination of flumazenil + AA or midazolam + AA, and injected intraperitoneally 30 minutes prior to testing. The rats were tested on the ElevatedPlus Maze (EPM) and the Forced Swim Test (FST). Data were analyzed using a two-tailed multivariate analysis of variance (MANOVA). Significance was found regarding the ratio of open arm time, maximum speed, and time spent mobile in the AA group and the midazolam + AA group (P<.05). Flumazenil decreased the anxiolytic effects, suggesting that AA modulates the benzodiazepine site on the GABAA receptor. Further studies are recommended to determine the efficacy of prolonged treatment for anxiety and depression.

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