Evaluation of wound healing effect of chitosan-based gel formulation containing vitexin. - GreenMedInfo Summary
Evaluation of wound healing effect of chitosan-based gel formulation containing vitexin.
Saudi Pharm J. 2020 Jan ;28(1):87-94. Epub 2019 Nov 20. PMID: 31933527
Acute or chronic wounds are one of the most common health problems worldwide and medicinal drugs or traditional remedies are often used in wound healing. Further studies regarding wound treatment are rapidly continuing. Vitexin is a phenolic compound, which is found in many medicinal plants, has different pharmacological effects such as anti-inflammatory, analgesic and antioxidant. In the present study, it is aimed to investigate the wound healing effect of formulation prepared as chitosan-based gel with vitexinand. Cytotoxicity and wound healing assays were used forand excisional wound model is used forstudies. Extracted tissues from wound area were histologically examined. Wound healing process was monitored on 7, 14 and 21st days. When wound construction was evaluated, chitosan-based gel formulation containing vitexin demonstrated significant effect compared to control group. Histological examinations demonstrated that skin regeneration was promoted by vitexin formulation. Significant cell proliferation was observed with vitexin/chitosan dispersion in the wound healing assay performed with NIH 3T3 and HaCaT cells. In conclusion, our test substance chitosan-based gel formulation containing vitexin significantly accelerated wound healing bothand.