Abstract Title:

Evidence for a manifold role of selenium in infertility.

Abstract Source:

Hormones (Athens). 2020 Mar ;19(1):55-59. Epub 2019 Nov 7. PMID: 31701489

Abstract Author(s):

Gesthimani Mintziori, Athanasios Mousiolis, Leonidas H Duntas, Dimitrios G Goulis

Article Affiliation:

Gesthimani Mintziori


This review aimed to assess the evidence from observational and interventional studies in humans and animals regarding the role of selenium (Se) in male and female infertility. As oxidative stress can seriously impair male, and possibly also female, reproductive functions, it can be speculated that the antioxidant properties of Se could constitute one of the pathways by which this element is involved in fertility. Specifically, there are strong indications that Se influences the growth, maturation, and replication of oocytes, though the precise mechanisms have not as yet been fully elucidated. Given that it is not clear at present which tissue sample (blood, serum, seminal plasma, sperm, or follicular fluid) renders the most accurate picture of Se concentration in terms of its role in reproduction, the data are still insufficient to recommend routine assessment of Se status in men and women seeking fertility. Nevertheless, the existing evidence, despite being of limited quantity and somewhat low quality, suggests that Se supplementation (<200μg/d) is possibly beneficial in men through its improvement of sperm motility. Well-designed, randomized control studies are needed to reveal the seemingly diverse protective/positive role of Se supplementation in men and women seeking fertility treatment.

Study Type : Review

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