Abstract Title:

Effect of puerarin on type II diabetes mellitus with orthopaedic footwear.

Abstract Source:

Pak J Pharm Sci. 2017 Sep ;30(5(Special)):1899-1903. PMID: 29084664

Abstract Author(s):

Qinyuan Yu, Wenzhong Han, Yixi Zhu, Hua Zhai

Article Affiliation:

Qinyuan Yu


In recent years, the antioxidant efficacy of puerarin has been recognized. However, there is less research on Puerarin used in diabetes. This paper analyzes the effect of puerarin on type II diabetes mellitus induced by streptozotocin combined with orthopaedic footwear. In this study, 80 Sprague Dawley (SD) rats were fed with high fat and high sucrose diet for one month, and 1% streptozotocin (STZ) was used to induce type II diabetes mellitus. After 6 weeks aerobic exercise and puerarin intervention in rats, the effect of aerobic exercise and puerarin intervention on antioxidant ability in diabetic rats was investigated. The results showed that aerobic exercise and puerarin intervention can improve the insulin resistance in rats. Meanwhile, the annual incidence of foot ulcers in diabetic patients is 2%, while orthopaedic footwear can reduce the probability of diabetic foot ulcers. In general, exercise and puerarin intervention can really play a role in the prevention and treatment of diabetes, such as improving the metabolic status of diabetic patients and reducing their dependence on drugs.

Study Type : Animal Study

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