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Article Publish Status: FREE
Abstract Title:

Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L.

Abstract Source:

Elife. 2019 Jun 24 ;8. Epub 2019 Jun 24. PMID: 31232686

Abstract Author(s):

Christina Chatzi, Yingyu Zhang, Wiiliam D Hendricks, Yang Chen, Eric Schnell, Richard H Goodman, Gary L Westbrook

Article Affiliation:

Christina Chatzi

Abstract:

Exercise is a potent enhancer of learning and memory, yet we know little of the underlying mechanisms that likely include alterations in synaptic efficacy in the hippocampus. To address this issue, we exposed mice to a single episode of voluntary exercise, and permanently marked activated mature hippocampal dentate granule cells using conditional Fos-TRAP mice. Exercise-activated neurons (Fos-TRAPed) showed an input-selective increase in dendritic spines and excitatory postsynaptic currents at 3 days post-exercise, indicative of exercise-induced structural plasticity. Laser-capture microdissection and RNASeq of activated neurons revealed that the most highly induced transcript was, a little-studied I-BAR domain-containing gene, which we hypothesized could be involved in membrane curvature and dendritic spine formation. shRNA-mediatedknockdown in vivo prevented the exercise-induced increases in spines and excitatory postsynaptic currents. Our results link short-term effects of exercise to activity-dependent expression of Mtss1L, which we propose as a novel effector of activity-dependent rearrangement of synapses.

Study Type : Animal Study
Additional Links
Therapeutic Actions : Exercise : CK(2795) : AC(411)

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