Exosomal microRNA-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA.
Mol Med Rep. 2021 May ;23(5). Epub 2021 Mar 24. PMID: 33760119
Aberrant microRNA (miRNA/miR) expression plays an important role in the pathogenesis of nasopharyngeal carcinoma (NPC). In the present study, the role and underlying molecular mechanism of miR‑301a‑3p in NPC cells were determined. It was observed that miR‑301a‑3p upregulation promoted NPC cell proliferation, migration, invasion and epithelial‑mesenchymal transition, whereas its downregulation resulted in the opposite effect. B‑cell translocation gene 1 (BTG1) mRNA was identified as the novel target of miR‑301a‑3p. BTG1 overexpression partially attenuated miR‑301a‑3p‑induced increase in cell proliferation and invasion. miR‑301a‑3p can be transferred by exosomes and positively regulate the proliferation and invasion of NPC cells. Altogether, the present study highlights that exosomal miR‑301a‑3p can promote NPC cell proliferation and invasion by repressing BTG1, thereby resulting in the development of NPC.