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Article Publish Status: FREE
Abstract Title:

Exosome-mediated human norovirus infection.

Abstract Source:

PLoS One. 2020 ;15(8):e0237044. Epub 2020 Aug 3. PMID: 32745122

Abstract Author(s):

Kyle V Todd, Ralph A Tripp

Article Affiliation:

Kyle V Todd

Abstract:

Human norovirus (HuNoV) is a leading cause of acute gastroenteritis. Outbreaks normally occur via the fecal-oral route. HuNoV infection is thought to occur by viral particle transmission, but increasing evidence suggests a function for exosomes in HuNoV infection. HuNoV is contained within stool-derived exosomes, and exosome-associated HuNoV has been shown to replicate in human intestinal enteroids. In this study, we examine exosome-associated HuNoV infection of Vero cells and show that exosomes containing HuNoV may attach, infect, and be passaged in Vero cells. These findings support earlier findings and have implications for developing HuNoV disease intervention strategies.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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