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Article Publish Status: FREE
Abstract Title:

Exosomes Modulate the Viral Replication and Host Immune Responses in HBV Infection.

Abstract Source:

Biomed Res Int. 2019 ;2019:2103943. Epub 2019 May 28. PMID: 31275965

Abstract Author(s):

Shuang Li, Shilin Li, Shaobo Wu, Limin Chen

Article Affiliation:

Shuang Li

Abstract:

Although current diagnosis and treatment of hepatitis B virus (HBV) infection can maintain viral suppression, new therapies need to be invented to sustain off-treatment virologic suppression and reduce side effects. Exosomes act as intercellular communicators to facilitate direct transfer of proteins, lipids, and nucleic acids between cellsand. Pioneering work has demonstrated that exosomal cargos changed markedly during HBV infection. An improved understanding of the functions of exosomes during HBV infection could lead to a powerful new strategy for preventing and treating HBV. In this review, we point out the role of exosomes in HBV infection: (1) exosomes could directly participate in HBV replication; (2) exosomes modulate immune response during HBV infections; (3) exosomal RNAs and proteins might be selected as novel biomarkers for the diagnosis of HBV infections; and (4) exosomes can also be designed as vaccines.

Study Type : In Vitro Study
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Additional Keywords : Exosomes : CK(312) : AC(199)

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Sayer Ji
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