Abstract Title:

Exploring the potentials of some compounds from Garcinia kola seeds towards identification of novel PDE-5 inhibitors in erectile dysfunction therapy.

Abstract Source:

Andrologia. 2021 Aug ;53(7):e14092. Epub 2021 May 4. PMID: 33945159

Abstract Author(s):

Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Rotdelmwa Filibus Maimako, Damilare Rotimi, Matthew Iyobhebhe, Omokolade Oluwaseyi Alejolowo, Charles Obiora Nwonuma, Tobiloba Christaina Elebiyo

Article Affiliation:

Oluwafemi Adeleke Ojo


Erectile dysfunction (ED) is one of the main challenges occurring among men worldwide, and is characterised by trouble getting or keeping steady erection during sexual intercourse. Various drugs like sildenafil, a phosphodiesterase-5 inhibitor (PDE-5) are freely available in the pharmacies, though normally associated with several adverse. This study was designed to assess the molecular relations obtainable between catechin, garcinal, garcinoic acid and d-tocotrienol compounds isolated from Garcinia kola and targeted receptor linked to ED. These processes include the molecular docking of catechin, garcinal, garcinoic acid, d-tocotrienol, and sildenafil to receptor: PDE-5 via AutoDock Vina. Following the docking of catechin, garcinal, garcinoic acid and d-tocotrienol with the PDE-5-receptor protein, we observed that all are protein inhibitors with garcinoic acid showing better binding affinity -10.0 kcal/mol with PDE-5 receptor relevant to ED. Hence, the results provided insights into the development of garcinoic acid as a replacement for present ED management, with further analysis worth considering.

Study Type : Animal Study

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