Abstract Title:

[Influence of 1.8 GHz microwave on DNA damage induced by 4 chemical mutagens].

Abstract Source:

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Jun ;23(3):163-6. PMID: 16124885

Abstract Author(s):

Bao-hong Wang, De-qiang Lu, Li-fen Jin, Wei Zheng, Jian-lin Lou, Hong-ping Deng, Qing-yu Li, Ji-liang He

Article Affiliation:

Bao-hong Wang


OBJECTIVE: To observe the influence of 1.8 GHz microwave (MW) specific absorption rate (SAR, 3 W/kg) on human lymphocytes DNA damage induced by 4 chemical mutagens [mitomycin C (MMC), bleomycin (BLM), methyl methanesulfonate (MMS), and 4-nitroquinoline 1-oxide (4NQO)].

METHODS: Comet assay in vitro was used to detect human lymphocyte DNA damage induced by 1.8 GHz MW, 4 chemical mutagens, and MW plus 4 chemicals 0 h and 21 h respectively after exposure. The time exposed to MW or mutagens was 2 h or 3 h respectively. The results were showed by tail length (TL) and tail moment (TM).

RESULTS: The difference of DNA damage between MW group and control group was not statistically significant (P>0.05). DNA damages in MW plus MMC groups and MW plus 4NQO groups were significantly greater than those in the corresponding concentrations of MMC groups and 4NQO groups (P<0.01 or P<0.05). However, MW did not enhance DNA damage induced by MMS and BLM (P>0.05).

CONCLUSION: Exposure to 1.8 GHz (SAR, 3 W/kg) microwave may not induce human lymphocyte DNA damage, but could enhance DNA damage induced by MMC and 4NQO.

Study Type : In Vitro Study

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Sayer Ji
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