[Influence of 1.8 GHz microwave on DNA damage induced by 4 chemical mutagens].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Jun ;23(3):163-6. PMID: 16124885
OBJECTIVE: To observe the influence of 1.8 GHz microwave (MW) specific absorption rate (SAR, 3 W/kg) on human lymphocytes DNA damage induced by 4 chemical mutagens [mitomycin C (MMC), bleomycin (BLM), methyl methanesulfonate (MMS), and 4-nitroquinoline 1-oxide (4NQO)].
METHODS: Comet assay in vitro was used to detect human lymphocyte DNA damage induced by 1.8 GHz MW, 4 chemical mutagens, and MW plus 4 chemicals 0 h and 21 h respectively after exposure. The time exposed to MW or mutagens was 2 h or 3 h respectively. The results were showed by tail length (TL) and tail moment (TM).
RESULTS: The difference of DNA damage between MW group and control group was not statistically significant (P>0.05). DNA damages in MW plus MMC groups and MW plus 4NQO groups were significantly greater than those in the corresponding concentrations of MMC groups and 4NQO groups (P<0.01 or P<0.05). However, MW did not enhance DNA damage induced by MMS and BLM (P>0.05).
CONCLUSION: Exposure to 1.8 GHz (SAR, 3 W/kg) microwave may not induce human lymphocyte DNA damage, but could enhance DNA damage induced by MMC and 4NQO.